Drying Solvents and Reagents

Introduction

As it is crucial for many of the compounds that are used in our group that all reagents and solvents are dried thouroughly, here are some common techniques.

Standard Solvents

The most commonly used solvents in our lab are dried using percolation under a nitrogen atmosphere over columns of alumina, molecular sieves, and supported copper oxygen scavenger (BASF R3-11).

Acetonitrile dry over molecular sieves
Bromobenzene dry over CaH2
Dichloromethane dry over CaH2
Diethylether percolation
Dimethylformamide molecular sieves
Cyclohexane dry over Na/K alloy
Fluorobenzene dry over CaH2
Hexane percolation
Pentane percolation
Tetrahydrofuran percolation
Toluene percolation

Deuterated solvents

Benzene-d6 dry over Na/K alloy and vacuum transfer
Bromobenzene-d5 dry over CaH2 and vacuum transfer
Dichloromethane-d2 dry over CaH2 and vacuum transfer
Tetrahydrofuran-d8 dry over Na/K alloy and vacuum transfer
Toluene-d8 dry over Na/K alloy and vacuum transfer
Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License